PATHOLOGY

Detailed explanation-1: -Targeted therapy is a type of cancer treatment that targets proteins that control how cancer cells grow, divide, and spread. It is the foundation of precision medicine.

Detailed explanation-2: -Antimetabolites are cell cycle specific. Antimetabolites are most effective during the S-phase of cell division because they primarily act upon cells undergoing synthesis of new DNA for formation of new cells. The toxicities associated with these drugs are seen in cells that are growing and dividing quickly.

Detailed explanation-3: -Therefore, the S phase is the most critical phase in the cell cycle. Many chemotherapeutic drugs mainly act on the S phase of cells. The G2 phase is the period from the completion of DNA replication to the beginning of mitosis.

Detailed explanation-4: -Mitotic inhibitors They work by stopping cells from dividing to form new cells, but can damage cells in all phases by keeping enzymes from making proteins needed for cell reproduction. Examples of mitotic inhibitors include the taxanes and vinca alkaloids. Taxanes include: Cabazitaxel.