PATHOLOGY

Detailed explanation-1: -In mitosis and meiosis, the spindle checkpoint blocks progression from metaphase to anaphase when spindle microtubules are disrupted or when their connections to the kinetochores of chromosomes are compromised.

Detailed explanation-2: -The M checkpoint occurs near the end of the metaphase stage of mitosis. The M checkpoint is also known as the spindle checkpoint because it determines whether all the sister chromatids are correctly attached to the spindle microtubules.

Detailed explanation-3: -The M checkpoint is also known as the spindle checkpoint: here, the cell examines whether all the sister chromatids are correctly attached to the spindle microtubules.