PATHOLOGY

Detailed explanation-1: -While the reason for liquefactive necrosis following ischemic injury in the brain is poorly understood, the release of digestive enzymes and constituents of neutrophils is the reason for liquefaction in infections. Gross Appearance: The tissue is in a liquid form and sometimes creamy yellow because of pus formation.

Detailed explanation-2: -In organs or tissues outside the CNS, liquefactive necrosis is most commonly encountered as part of pyogenic (pus-forming) bacterial infection with suppurative (neutrophil-rich) inflammation (see also Chapter 3) and is observed at the centers of abscesses or other collections of neutrophils.

Detailed explanation-3: -Cell Injury. This is liquefactive necrosis in the brain of a patient who suffered a “stroke” with focal loss of blood supply to a portion of cerebrum. This type of infarction leads to necrosis which is marked by loss of neurons and neuroglial cells and the formation of a clear space at the center left.