PATHOLOGY

Detailed explanation-1: -Vacuolization is the formation of vacuoles or vacuole-like structures, within or adjacent to cells. Perinuclear vacuolization of epidermal keratinocytes is most likely inconsequential when not observed in combination with other pathologic findings.

Detailed explanation-2: -Vacuolization refers to the state or the process of forming vacuoles. The vacuoles may form inside or adjacent to the cells. 1. There are many instances in which vacuoles form. One of which is the neurodegenerative diseases in humans and animals caused by prions.

Detailed explanation-3: -Oxygen deprivation. A hypoxic state results in reduced aerobic oxidative respiration, which results in cell injury. Physical agents. Chemical agents and drugs. Immunologic reactions. Infectious agents. Nutritional imbalances. Genetic derangement. Hypoxia and ischemic cell injury.