PATHOLOGY

PATHOLOGY MCQ

CELL DAMAGE

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Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]

People who have leukemia, a cancer that affects white blood cells, are often given Cytarabine. This drug inhibits the synthesis of DNA. Which phase of the cell cycle is most affected by Cytarabine?

A	G1 phase
B	S phase
C	G2 phase
D	M phase

Explanation:

Detailed explanation-1: -Cytarabine is a cell cycle phase-specific antineoplastic agent, affecting cells only during the S-phase of cell division.

Detailed explanation-2: -Cytotoxicity is highly specific for the S phase of the cell cycle. Cytarabine acts through direct DNA damage and incorporation into DNA.

Detailed explanation-3: -Through DNA replication, genetic information is accurately transmitted to the daughter cells of M phase division to ensure the stability of genetic traits. Therefore, the S phase is the most critical phase in the cell cycle. Many chemotherapeutic drugs mainly act on the S phase of cells.

Detailed explanation-4: -Interaction of Chemotherapy and Radiation The G2/M phase has been identified as the most radiation-sensitive phase of the cell cycle and the S phase as the most radiation-resistant phase. In addition, many cytotoxic chemotherapeutic agents are cell cycle specific.

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