PATHOLOGY

Detailed explanation-1: -The intrinsic apoptosis pathway involves mitochondria outer membrane permeabilization (MOMP; see later the section for MOMP). Upon MOMP, proapoptotic proteins are released from the mitochondrial intermembrane space into the cytoplasm.

Detailed explanation-2: -Apoptosis can be triggered in two ways: (a) through an intrinsic pathway which is regulated by the protein Bcl-2 and is activated by internal signals. This pathway sub-serves cells that are subjected to stress such as DNA damage or growth factor deprivation.