PATHOLOGY

Detailed explanation-1: -The two “sister” chromatids are joined at a constricted region of the chromosome called the centromere. During cell division, spindle fibers attach to the centromere and pull each of the sister chromatids to opposite sides of the cell. Soon after, the cell divides in two, resulting in daughter cells with identical DNA.

Detailed explanation-2: -Sister chromatids are physically held together by cohesin, which is a protein complex consisting of four core subunits (Fig. 1).

Detailed explanation-3: -The two identical chromosomes that result from DNA replication are referred to as sister chromatids. Sister chromatids are held together by proteins at a region of the chromosome called the centromere. Chromosomes undergo additional compaction at the beginning of mitosis.