PATHOLOGY

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PATHOLOGY MCQ

CELL DAMAGE

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
The list below describes some of the events associated with normal cell division. 1. Nuclear membrane formation around each set of newly formed chromosomes 2. Centrioles move to poles and nuclear envelope disappears 3. Replication of each chromosome 4. Movement of single stranded chromosomes to opposite ends of the spindle. What is the normal sequence in which these events occur?
A
3-4-2-1
B
1-2-3-4
C
3-2-4-1
D
4-3-1-2
Explanation: 

Detailed explanation-1: -The cell cycle is a 4-stage process consisting of Gap 1 (G1), synthesis (S), Gap 2 (G2), and mitosis (M), which a cell undergoes as it grows and divides. After completing the cycle it either starts the process again from G1 or exits through G0. From G0, the cell can undergo terminal differentiation.

Detailed explanation-2: -During mitosis (nuclear division), the chromosomes condense, the nuclear envelope of most cells breaks down, the cytoskeleton reorganizes to form the mitotic spindle, and the chromosomes move to opposite poles. Chromosome segregation is then usually followed by cell division (cytokinesis).

Detailed explanation-3: -Today, mitosis is understood to involve five phases, based on the physical state of the chromosomes and spindle. These phases are prophase, prometaphase, metaphase, anaphase, and telophase.

Detailed explanation-4: -The correct option is Condensation → Nuclear membrane disassembly → Arrangement at equator → Centromere division → Segregation → Telophase. During prophase, the chromosomes condense, the nucleolus disappears, and the nuclear envelope breaks down.

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