PATHOLOGY

Detailed explanation-1: -The spindle checkpoint ensures the fidelity of chromosome transmission by delaying anaphase until all chromatid pairs have formed proper links to the mitotic spindle. Sister chromatids attach to spindle microtubules (MTs) via kinetochores, which are multiprotein complexes that assemble on centromeric (CEN) DNA.

Detailed explanation-2: -The M checkpoint is also known as the spindle checkpoint: here, the cell examines whether all the sister chromatids are correctly attached to the spindle microtubules.

Detailed explanation-3: -The cell cycle is controlled at three checkpoints. The integrity of the DNA is assessed at the G1 checkpoint. Proper chromosome duplication is assessed at the G2 checkpoint.

Detailed explanation-4: -The M checkpoint is also known as the spindle checkpoint because it determines if all the sister chromatids are correctly attached to the spindle microtubules.

Detailed explanation-5: -M checkpoint – nuclear division setup check It is also called the spindle checkpoint because the cell examines whether all sister chromatids are correctly attached to the spindle microtubules that separate them. If not, the cell pauses mitosis until all sister chromatids have been attached in the right way.