PATHOLOGY

Detailed explanation-1: -In the eukaryotic cell cycle, chromosome duplication occurs during “S phase” (the phase of DNA synthesis) and chromosome segregation occurs during “M phase” (the mitosis phase).

Detailed explanation-2: -During S phase, an enzyme called helicase unwinds the DNA strand, in the same way that you would unzip a zipper. The two single DNA strands can then be used as templates to form two identical double DNA strands.

Detailed explanation-3: -In S phase, the cell synthesizes a complete copy of the DNA in its nucleus. It also duplicates a microtubule-organizing structure called the centrosome. The centrosomes help separate DNA during M phase.

Detailed explanation-4: -S phase is the period during which DNA replication occurs.

Detailed explanation-5: -DNA replicates in the S phase of the cell cycle and initiates at specific regions in the DNA sequence known as DNA replication ‘origins’. A number of proteins participate in DNA replication and the process is subject to scrutiny by cell surveillance mechanisms called cell cycle checkpoints.