PATHOLOGY

Detailed explanation-1: -To facilitate the adhesion, white blood cells migrate toward the vessel walls in blood flow through a process called margination. The margination of white cells depends on a number of conditions including local hematocrit, flow rate, red blood cell aggregation, and the deformability of both red and white cells.

Detailed explanation-2: -This process of leukocyte accumulation at the periphery of vessels is called margination. Afterwards, leukocytes tumble (roll over and over) slowly along the endothelial surface and adhere transiently. This process of brief, loose sticking of leukocytes to the endothelium is called Rolling.