PATHOLOGY

Detailed explanation-1: -The three family members are E-selectin (endothelial), L-selectin (leukocyte), and P-selectin (platelet). The best-characterized ligand for the three selectins is P-selectin glycoprotein ligand-1 (PSGL-1), which is a mucin-type glycoprotein expressed on all white blood cells.

Detailed explanation-2: -Adhesion is the attraction between two dissimilar phases. There is no single theory to explain adhesion, but it is commonly divided into mechanical interlocking and physical and chemical bonding. Most typically adhesion occurs because of the combination of different mechanisms explained below.