PATHOLOGY

Detailed explanation-1: -The p53 gene like the Rb gene, is a tumor suppressor gene, i.e., its activity stops the formation of tumors. If a person inherits only one functional copy of the p53 gene from their parents, they are predisposed to cancer and usually develop several independent tumors in a variety of tissues in early adulthood.

Detailed explanation-2: -The p53 proto-oncogene can act as a suppressor of transformation: Cell.