PATHOLOGY

Detailed explanation-1: -The TP53 gene provides instructions for making a protein called tumor protein p53 (or p53). This protein acts as a tumor suppressor, which means that it regulates cell division by keeping cells from growing and dividing (proliferating) too fast or in an uncontrolled way.

Detailed explanation-2: -Tumor suppressor genes are genes that code for the negative regulator proteins, the type of regulator that-when activated-can prevent the cell from undergoing uncontrolled division.

Detailed explanation-3: -For example, TP53 is an important tumor suppressor gene. It codes for the p53 protein, which helps keep cell division under control. Inherited changes in the TP53 gene can lead to Li-Fraumeni syndrome.

Detailed explanation-4: -Genes that normally block cell cycle progression are known as tumor suppressors. Tumor suppressors prevent the formation of cancerous tumors when they are working correctly, and tumors may form when they mutate so they no longer work.

Detailed explanation-5: -TSGs encode proteins that normally serve as a brake on cell growth. When such genes are mutated, the brake may be lifted, resulting in runaway cell growth known as cancer.