PATHOLOGY

Detailed explanation-1: -What would happen if the G2 phase didn’t function properly? No cellular proteins could be made. The DNA would not be replicated. The spindle apparatus would not form.

Detailed explanation-2: -What might happen if the G2 Checkpoint stopped working? The cells could be damaged. They may not have the adequate size, damaged DNA and other abnormalities which may not allow for mitosis and division.

Detailed explanation-3: -Cell cycle checkpoints provide the cell time to complete replication and repair the DNA damage before it can continue to the next cell cycle phase. The G2/M checkpoint plays an especially important role in ensuring the propagation of error-free copies of the genome to each daughter cell.

Detailed explanation-4: -Protein Synthesis during G2 Phase Is Required for Normal Mitotic Progression. So far, we have shown that inhibition of either Wee1/Myt1 or p38 can overcome a cycloheximide-induced arrest and allow G2 phase cells to progress into mitosis in the absence of protein synthesis.

Detailed explanation-5: -G1 is followed by S phase (synthesis), during which DNA replication takes place. The completion of DNA synthesis is followed by the G2 phase (gap 2), during which cell growth continues and proteins are synthesized in preparation for mitosis.