PATHOLOGY MCQ
CELL DAMAGE
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Which cell cycle checkpoint verifies cell size and checks the original DNA for damage?
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G1 checkpoint
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S checkpoint
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G2 checkpoint
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M checkpoint
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Explanation:
Detailed explanation-1: -At the G2 checkpoint, the cell checks for: DNA damage.
Detailed explanation-2: -G1 checkpoint – size and nutrient verification The cell verifies that it is large enough to divide, that its DNA is intact, and if there is enough access to nutrients and stimulating growth factors. If it passes the G1 checkpoint, it irreversibly commits to complete the whole cell cycle and divide.
Detailed explanation-3: -Cell Cycle: DNA Damage Checkpoints The most well-known mechanism for DNA damaged-induced G1 arrest is that mediated by the tumor-suppressor protein p53 in mammalian cells. DNA damage stabilizes the p53 protein and activates its transcription function.
There is 1 question to complete.