PATHOLOGY MCQ
CELL DAMAGE
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Which checkpoint ensures that sister chromatids are positioned to split correctly?
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G1 checkpoint
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G2 checkpoint
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S checkpoint
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M checkpoint
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Explanation:
Detailed explanation-1: -The segregation of sister chromatids at anaphase is under the mechanical control of the mitotic spindle.
Detailed explanation-2: -The spindle checkpoint is a key regulator of chromosome segregation in mitosis and meiosis. Its function is to prevent precocious anaphase onset before chromosomes have achieved bipolar attachment to the spindle.
Detailed explanation-3: -The G2 checkpoint prevents cells from entering mitosis when DNA is damaged, providing an opportunity for repair and stopping the proliferation of damaged cells. Because the G2 checkpoint helps to maintain genomic stability, it is an important focus in understanding the molecular causes of cancer.
There is 1 question to complete.