PATHOLOGY

Detailed explanation-1: -The mitotic spindle also begins to develop during prophase. As the cell’s two centrosomes move toward opposite poles, microtubules gradually assemble between them, forming the network that will later pull the duplicated chromosomes apart.

Detailed explanation-2: -The microtubules that emanate from the centrosome terminate in the pericentriolar material, not the centrioles, and it is the pericentriolar material that initiates microtubule assembly.

Detailed explanation-3: -During the first stage of mitosis, called prophase, we first see the classic chromosome structure. This occurs through a condensation process. At the same time, protein strands called microtubules appear from the centrosomes in animals.

Detailed explanation-4: -During prophase, the spindle also begins to form as the two pairs of centrioles move to opposite poles and microtubules begin to polymerize from the duplicated centrosomes.