PATHOLOGY

Detailed explanation-1: -A normal cell with unfixable DNA damaged will undergo apoptosis. A cancer cell with unfixable DNA damage will not undergo apoptosis and will instead continue dividing.

Detailed explanation-2: -Cancer cells can ignore the signals that tell them to self destruct. So they don’t undergo apoptosis when they should. Scientists call this making cells immortal.

Detailed explanation-3: -Apoptosis occurs normally during development and aging and as a homeostatic mechanism to maintain cell populations in tissues. Apoptosis also occurs as a defense mechanism such as in immune reactions or when cells are damaged by disease or noxious agents (Norbury and Hickson, 2001).

Detailed explanation-4: -If upregulation of the antiapoptotic proteins is halted or disrupted, then the proapoptotic proteins can trigger apoptosis. Targeting primed cells with an inhibitor of antiapoptotic proteins could result in apoptosis and the death of the tumor cell.

Detailed explanation-5: -Cancer is one of the scenarios where too little apoptosis occurs, resulting in malignant cells that will not die. The mechanism of apoptosis is complex and involves many pathways.