PATHOLOGY

Detailed explanation-1: -Therefore, as a cell increases in size, its surface area-to-volume ratio decreases. This same principle would apply if the cell had the shape of a cube (below). If the cell grows too large, the plasma membrane will not have sufficient surface area to support the rate of diffusion required for the increased volume.

Detailed explanation-2: -Smaller cells have a much greater surface area to volume ratio allowing material to diffuse throughout the entire volume of the cell quickly and efficiently.