PATHOLOGY MCQ
CELL DAMAGE
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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The muscle cell will be stopped at the G1 checkpoint and sent to G0 phase.
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The G2 checkpoint will stop the cell from continuing in the cell cycle.
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The cell will get stuck at the spindle checkpoint.
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The cell will continue on to cytokinesis.
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Detailed explanation-1: -What might happen if the G2 Checkpoint stopped working? The cells could be damaged. They may not have the adequate size, damaged DNA and other abnormalities which may not allow for mitosis and division.
Detailed explanation-2: -The G2/M checkpoint prevents cells from entering mitosis when DNA is damaged in order to afford these cells an opportunity to repair the damaged DNA before propagating genetic defects to the daughter cells. If the damage is irreparable, checkpoint signaling might activate pathways that lead to apoptosis.
Detailed explanation-3: -Damage to DNA and other external factors are evaluated at the G1 checkpoint; if conditions are inadequate, the cell will not be allowed to continue to the S phase of interphase. The G2 checkpoint ensures all of the chromosomes have been replicated and that the replicated DNA is not damaged before cell enters mitosis.
Detailed explanation-4: -In order to pass the G2 checkpoint, all of the DNA must be duplicated and repaired before entering M phase.