PATHOLOGY

Detailed explanation-1: -Growth hormone levels are increased by sleep, stress, exercise and low glucose levels in the blood. They also increase around the time of puberty. Growth hormone release is lowered in pregnancy and if the brain senses high levels of growth hormone or insulin-like growth factors already in the blood.

Detailed explanation-2: -In addition, age, gender, pubertal status, food, exercise, fasting, sleep and body composition play important regulatory roles. GH acts both directly through its own receptors and indirectly through the induced production of IGF-I.

Detailed explanation-3: -Any increase in muscle size due to use of synthetic growth hormone is actually the result of an increase in connective tissue, which does not contribute to muscle strength. For this reason, use of synthetic growth hormone does not lead to increase muscle strength.

Detailed explanation-4: -Ghrelin also regulates growth hormone-releasing hormone and growth hormone release.