PATHOLOGY

Detailed explanation-1: -The primary cells that induce the extrinsic pathway of apoptosis are NK and CTL lymphocytes. NK cells are lymphocytes, yet are part of the innate immune system, whereas CTLs are T lymphocytes of the adaptive immune system, and as such, undergo clonal selection in response to an antigen and can form memory lymphocytes.

Detailed explanation-2: -In both the intrinsic and extrinsic pathway of apoptosis, signaling results in the activation of a family of Cys (Cysteine) proteases, named caspases, that act in a proteolytic cascade to dismantle and remove the dying cell (1).