PATHOLOGY MCQ
CELL DAMAGE
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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They undergo apoptosis.
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They do not respond to growth inhibitors
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They respond to growth inhibitors.
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None of the above
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Detailed explanation-1: -So, the correct answer is ‘They show contact inhibition’.
Detailed explanation-2: -Most cancer-causing DNA changes occur in sections of DNA called genes. These changes are also called genetic changes. A DNA change can cause genes involved in normal cell growth to become oncogenes. Unlike normal genes, oncogenes cannot be turned off, so they cause uncontrolled cell growth.
Detailed explanation-3: -Cancer cells grow and divide at an abnormally rapid rate, are poorly differentiated, and have abnormal membranes, cytoskeletal proteins, and morphology. The abnormality in cells can be progressive with a slow transition from normal cells to benign tumors to malignant tumors.
Detailed explanation-4: -Contact inhibition is lost in cancer cells. Cancer cells do not arrest their growth but it continues to proliferate and piles up on the top of each other forming a multilayered foci. This growth arrest is signaled by membrane proteins and mediated by the elevated levels of p27Kip1 cyclin-dependent kinase inhibitor.