PATHOLOGY

Detailed explanation-1: -In late prophase (sometimes also called prometaphase), the mitotic spindle begins to capture and organize the chromosomes. The chromosomes become even more condensed, so they are very compact. The nuclear envelope breaks down, releasing the chromosomes.

Detailed explanation-2: -Prometaphase is the second phase of mitosis, the process that separates the duplicated genetic material carried in the nucleus of a parent cell into two identical daughter cells. During prometaphase, the physical barrier that encloses the nucleus, called the nuclear envelope, breaks down.

Detailed explanation-3: -When prophase is complete, the cell enters prometaphase-the second stage of mitosis. During prometaphase, phosphorylation of nuclear lamins by M-CDK causes the nuclear membrane to break down into numerous small vesicles. As a result, the spindle microtubules now have direct access to the genetic material of the cell.

Detailed explanation-4: -Prometaphase II The nuclear envelopes are completely broken down, and the spindle is fully formed. Each sister chromatid forms an individual kinetochore that attaches to microtubules from opposite poles.

Detailed explanation-5: -These phases are prophase, prometaphase, metaphase, anaphase, and telophase. Cytokinesis is the final physical cell division that follows telophase, and is therefore sometimes considered a sixth phase of mitosis.