PATHOLOGY

Detailed explanation-1: -Key transitions in the cell cycle are regulated by the activities of various protein kinase complexes composed of cyclin and cyclin-dependent kinase (Cdk) molecules.

Detailed explanation-2: -Wee1 is the principal gatekeeper for both G2/M and S-phase checkpoints, where it plays a key role in cell cycle regulation and DNA damage repair.

Detailed explanation-3: -Protein machineries embedded in the membranes of our cells act as ‘gatekeepers’ controlling everything transported in and out of every cell in our bodies. Because these machineries, called membrane embedded proteins, are vital to the way our bodies function they are the target of at least 40% of drugs.

Detailed explanation-4: -Two groups of proteins, called cyclins and cyclin-dependent kinases (Cdks), are responsible for the progress of the cell through the various checkpoints. The levels of the four cyclin proteins fluctuate throughout the cell cycle in a predictable pattern.

Detailed explanation-5: -Checkpoints are controlled by Cyclin and CDK At cell cycle checkpoints, the cyclin-dependent kinases phosphorylate their target proteins, activating them to begin the processes of the next phase of the cell cycle.