PATHOLOGY

Detailed explanation-1: -The TP53 gene provides instructions for making a protein called tumor protein p53 (or p53). This protein acts as a tumor suppressor, which means that it regulates cell division by keeping cells from growing and dividing (proliferating) too fast or in an uncontrolled way.

Detailed explanation-2: -p53 is a tumor suppressor protein that mediates cell growth and death, as well as modulates expression of several proteins that control the cell cycle.

Detailed explanation-3: -Tumor suppressor genes are normal genes that slow down cell division or tell cells to die at the right time (a process known as apoptosis or programmed cell death). When tumor suppressor genes don’t work properly, cells can grow out of control, which can lead to cancer.

Detailed explanation-4: -A tumor suppressor gene encodes a protein that acts to regulate cell division, keeping it in check. When a tumor suppressor gene is inactivated by a mutation, the protein it encodes is not produced or does not function properly, and as a result, uncontrolled cell division may occur.

Detailed explanation-5: -Tumor suppressor genes are genes that code for the negative regulator proteins, the type of regulator that-when activated-can prevent the cell from undergoing uncontrolled division.