PATHOLOGY

Detailed explanation-1: -Adrenocorticotropic hormone (ACTH) is a hormone your pituitary gland releases that plays a large role in how your body responds to stress. The release of ACTH triggers your adrenal glands to produce cortisol, the “stress hormone, ‘’ and androgens (a group of sex hormones).

Detailed explanation-2: -The hypothalamus produces corticotropin-releasing hormone (CRH) that stimulates the pituitary gland to secrete adrenocorticotropin hormone (ACTH). ACTH then stimulates the adrenal glands to make and release cortisol hormones into the blood.

Detailed explanation-3: -The ACTH hormone is the primary regulator of cortisol production synthesized in the human adrenal fasciculate cells. ACTH is a post-translational product of the proopiomelanocortin protein (POMC), which is synthesized in the corticotroph cells of the anterior pituitary gland. ACTH is a 39-amino acid peptide.