PATHOLOGY

Detailed explanation-1: -In gigantism, the excessive amount of growth hormone (GH) accelerates the growth of muscle, bones and connective tissue. This leads to an abnormally increased height as well as several soft tissue changes. When left untreated or unmanaged, some people with gigantism have grown over 8 feet tall.

Detailed explanation-2: -Acromegaly is a hormonal disorder that develops when your pituitary gland produces too much growth hormone during adulthood. When you have too much growth hormone, your bones increase in size. In childhood, this leads to increased height and is called gigantism.

Detailed explanation-3: -Gigantism is a serious condition that is nearly always caused by an adenoma, a tumor of the pituitary gland. Gigantism occurs in patients who had excessive growth hormone in childhood. The pituitary tumor cells secrete too much growth hormone (GH), leading to many changes in the body.

Detailed explanation-4: -Gigantism (Greek: , gígas, “giant", plural , gígantes), also known as giantism, is a condition characterized by excessive growth and height significantly above average. In humans, this condition is caused by over-production of growth hormone in childhood, resulting in people up to 2.7 m (9.0 ft) in height.

Detailed explanation-5: -Gigantism is very similar to acromegaly. Acromegaly is also caused by excess growth hormone secretion however, this happens during adulthood rather than childhood. This means that height is normal as the growth plates have fused before the excess growth hormone secretion occurs.