PATHOLOGY

Detailed explanation-1: -Though widely known as the body’s stress hormone, Cortisol has a variety of effects on different functions throughout the body. It is the main glucocorticoid released from the zona fasciculata layer of the adrenal cortex.

Detailed explanation-2: -Glucocorticoids are secreted by the middle region of the adrenal cortex. The principal glucocorticoid is cortisol, which increases blood glucose levels. The third group of steroids secreted by the adrenal cortex is the gonadocorticoids, or sex hormones. These are secreted by the innermost region.

Detailed explanation-3: -Glucocorticoids are steroid hormones produced by the adrenal cortex. They have pleiotropic effects and contribute substantially to the maintenance of resting and stress-related homeostasis.

Detailed explanation-4: -Glucocorticoids synthesized in the adrenal cortex in response to adrenocorticotrophic hormone (ACTH) stimulate gluconeogenesis to provide energy for the “flight or fight” response. The response to stress combines suppressive and stimulating actions of glucocorticoids for the ultimate goal of preservation of self.

Detailed explanation-5: -For example, glucocorticoids regulate metabolic activity, immune function, and behavior (84). Circulating glucocorticoid levels increase in response to a variety of stressors under control of the hypothalamic-pituitary-adrenal (HPA) axis.