PATHOLOGY

Detailed explanation-1: -Aldosterone is controlled by the renin-angiotensin system, while the rest of the adrenal glands’ hormone production is controlled by adrenocorticotropic hormone (ACTH). Therefore, in cases of Addison’s disease caused by pituitary dysfunction, adrenal insufficiency will exist, but with appropriate aldosterone levels.

Detailed explanation-2: -aldosterone, a steroid hormone secreted by the adrenal glands. Aldosterone serves as the principal regulator of the salt and water balance of the body and thus is categorized as a mineralocorticoid. It also has a small effect on the metabolism of fats, carbohydrates, and proteins.

Detailed explanation-3: -Aldosterone produces these effects by affecting electrolyte transport in both PC and IC. In PC, aldosterone regulates the expression and activity of epithelial sodium channel (ENaC) leading to increased Na+ reabsorption from the filtrate into the circulation.