PATHOLOGY

Detailed explanation-1: -Acromegaly and gigantism are disorders of growth hormone hypersecretion. The most common cause is a growth hormone (GH) secreting adenoma in the pituitary gland. Gigantism occurs when growth hormone hypersecretion occurs before the fusion of the long bone epiphysis and is characterized by tall stature.

Detailed explanation-2: -Gigantism is abnormal growth due to an excess of growth hormone (GH) during childhood.

Detailed explanation-3: -Growth hormone (GH) hypersecretion in the human may be due to a GH-secreting tumor, to a GH-releasing-hormone (GHRH) secreting tumor, to disorders of GH feedback regulatory mechanisms, or to functional disturbance of GH regulation in association with systemic disorders, malnutrition, or psychiatric disease (Table 1).

Detailed explanation-4: -Hypersecretion is when an excess of one or more hormone is secreted from a gland. Hyposecretion is when the amount of hormones that are released is too low. There are many types of disorders that can result when too much or too little of a hormone is released.