PATHOLOGY

Detailed explanation-1: -GPCRs are a large family of cell surface receptors that respond to a variety of external signals. Binding of a signaling molecule to a GPCR results in G protein activation, which in turn triggers the production of any number of second messengers.

Detailed explanation-2: -GPCRs are found in the cell membranes of a wide range of organisms, including mammals, plants, microorganisms, and invertebrates.

Detailed explanation-3: -G-protein-coupled receptors (GPCRs), also called metabotropic receptors, are membrane-bound proteins that activate G-proteins after binding neurotransmitters.

Detailed explanation-4: -G-protein interactions and inhibition of cellular reactions. GH-releasing hormone binds to its receptor (R1) and activates the Gs-protein that turns on adenylyl cyclase (AC) to synthesize cyclic adenosine monophosphate (cAMP) from ATP. cAMP acts as a second messenger to mediate release of GH.