PATHOLOGY

Detailed explanation-1: -Cushing disease occurs when a pituitary adenoma, a noncancerous (benign) tumor on the pea-size pituitary gland, makes too much adrenocorticotropic hormone (ACTH). In response, the body’s two adrenal glands, one atop each kidney, make too much cortisol.

Detailed explanation-2: -With Cushing disease, the pituitary gland releases too much ACTH. ACTH stimulates production and release of cortisol, a stress hormone. Too much ACTH causes the adrenal glands to make too much cortisol. Cortisol is normally released during stressful situations.

Detailed explanation-3: -Cushing’s syndrome happens when you have too many corticosteroids in your body. When the disorder often starts with the pituitary gland, the condition is called Cushing’s syndrome. The gland makes too much adrenocorticotropin hormone (ACTH). That causes the adrenal glands to make too many corticosteroids.

Detailed explanation-4: -Pituitary Cushing’s is a condition in which the pituitary gland (an organ of the endocrine system) secretes excess adrenocorticotropic hormone (ACTH). Causes, incidence, and risk factors: Cushing’s disease is a form of Cushing’s syndrome, in which excess cortisol (a stress hormone) is secreted.

Detailed explanation-5: -High ACTH and high cortisol levels: This may mean Cushing’s disease. Low ACTH and high cortisol levels: This may mean Cushing’s syndrome or a tumor of the adrenal gland. High ACTH and low cortisol levels: This may mean Addison disease.