PATHOLOGY

Detailed explanation-1: -Gastrin is a peptide hormone primarily responsible for enhancing gastric mucosal growth, gastric motility, and secretion of hydrochloric acid (HCl) into the stomach. It is present in G cells of the gastric antrum and duodenum.

Detailed explanation-2: -The GI hormones that regulate gut mucosal growth positively or negatively include gastrin, CCK, secretin, somatostatin, ghrelin, bombesin, and gastrin-releasing peptide (GRP).

Detailed explanation-3: -Gastrin is a hormone that is produced by ‘G’ cells in the lining of the stomach and upper small intestine, and released into the blood circulation. During a meal, gastrin stimulates the stomach to release gastric acid (hydrochloric acid).

Detailed explanation-4: -Gastrin stimulates the secretion of gastric and pancreatic juice, insulin and glucagon, motility of the stomach and intestine, increases the tone of the lower esophageal sphincter and has a trophic effect on the mucous membrane of the digestive tract.

Detailed explanation-5: -Large quantities of fluid are transported in the gastrointestinal (GI) tract for secretion of saliva, gastric juice, bile and pancreatic fluid, and for absorption of fluid in the intestine.