PATHOLOGY

Detailed explanation-1: -The pituitary gland in your endocrine system uses gonadotropin-releasing hormone (GnRH) to stimulate the production of follicle-stimulating hormone and luteinizing hormone. These gonadotropins (hormones) make the sex hormones testosterone, estrogen and progesterone.

Detailed explanation-2: -Follicle stimulating hormone (or FSH) is one of the gonadotrophic hormones; the other being luteinising hormone (or LH). Both are released by the pituitary gland into the bloodstream.

Detailed explanation-3: -Kisspeptin signals directly to the hypothalamic GnRH neurons via kisspeptin receptor to release GnRH into the portal circulation, which in turn stimulates the anterior pituitary gonadotropes to produce LH and FSH (124, 150).

Detailed explanation-4: -These two hormones are secreted from cells in the anterior pituitary called gonadotrophs. Most gonadotrophs secrete only LH or FSH, but some appear to secrete both hormones. As described for thyroid-simulating hormone, LH and FSH are large glycoproteins composed of alpha and beta subunits.