PATHOLOGY

Detailed explanation-1: -Hypothyroidism happens when your thyroid doesn’t create and release enough thyroid hormone into your body. This makes your metabolism slow down, affecting you entire body. Also known as underactive thyroid disease, hypothyroidism is fairly common. When your thyroid levels are extremely low, this is called myxedema.

Detailed explanation-2: -Myxedema also refers to the swelling of the skin and soft tissue that occurs in patients who are hypothyroid. Myxedema coma occurs when the body’s compensatory responses to hypothyroidism are overwhelmed by a precipitating factor such as infection.

Detailed explanation-3: -Most cases of an underactive thyroid are caused by the immune system attacking the thyroid gland and damaging it, or by damage that occurs as a result of treatments for thyroid cancer or an overactive thyroid.

Detailed explanation-4: -Pathophysiology. Myxedema coma occurs as a result of long-standing, undiagnosed, or undertreated hypothyroidism and is usually precipitated by a systemic illness. Myxedema coma can result from any of the causes of hypothyroidism, most commonly chronic autoimmune thyroiditis.