PATHOLOGY

Detailed explanation-1: -Addison’s disease is caused by damage to the adrenal glands. The adrenal glands sit just above the kidneys. As part of the endocrine system, they make hormones that affect almost every organ and tissue in the body. Damage to these glands results in too little of the hormone cortisol and, often, the hormone aldosterone.

Detailed explanation-2: -Addison’s disease is caused by the under secretion of cortisol. As cortisol is a part of adrenal cortex, so when adrenal glands are not able to produce enough hormone, it will cause adrenal insufficiency or Addison’s disease.

Detailed explanation-3: -The most common cause of Addison’s disease is an autoimmune response, which occurs when your immune system attacks healthy tissues for an unknown reason. With Addison’s disease, your immune system attacks the outer portion of your adrenal glands (the adrenal cortex), where they make cortisol and aldosterone.

Detailed explanation-4: -Addison’s disease occurs when the adrenal glands are damaged and can’t make enough of the hormone cortisol and sometimes the hormone aldosterone.

Detailed explanation-5: -Addison’s disease (also known as primary adrenal insufficiency or hypoadrenalism) is a rare disorder of the adrenal glands. The adrenal glands are two small glands that sit on top of the kidneys. They produce essential hormones: cortisol, aldosterone and adrenaline.