PATHOLOGY

Detailed explanation-1: -The thyroid hormone receptors, TR1, TR1, and other subtypes, are members of the nuclear receptor superfamily that mediate the action of thyroid hormone signaling in numerous tissues to regulate important physiological and developmental processes.

Detailed explanation-2: -Type II nonsteroid nuclear receptors include the thyroid hormone receptors (TR and ), retinoic acid receptors (RAR, , and ), vitamin D receptor (VDR), and peroxisome proliferator-activated receptors (PPAR, , and ). Members of this family heterodimerize with the retinoid X receptor (RXR).

Detailed explanation-3: -At the cellular level, THs bind to thyroid hormone receptors (TRs) that are members of the nuclear hormone receptor family. TRs act as ligand-activated transcription factors that bind to their cognate thyroid hormone response elements (TREs) in the promoters of target genes.

Detailed explanation-4: -The thyroid hormone receptor (TR) is a type of nuclear receptor that is activated by binding thyroid hormone. TRs act as transcription factors, ultimately affecting the regulation of gene transcription and translation.

Detailed explanation-5: -Recent investigations have shown that the receptors are part of the v-erbA related super family of nuclear hormone receptors. At least two types of T3 receptors (TR) exist, one coded by a gene on chromosome 3 (TR beta) and a second coded on chromosome 17 (hTR alpha).