PATHOLOGY

Detailed explanation-1: -The classic androgen biosynthesis pathway in the adrenal zona reticularis and the gonads. Androgen precursors and active androgens are produced by both the adult adrenal and gonads by the 5 pathway from pregnenolone to DHEA (Fig. 3). This pathway is also referred to as the ‘classic androgen biosynthesis pathway’.

Detailed explanation-2: -With limited water-solubility, steroid hormones must be transported through the blood bound to specific carrier proteins.

Detailed explanation-3: -Which of the following hormones would bind to receptors located on the inside of a cell? Testosterone is a steroid hormone, therefore it will diffuse through the membrane and bind to cytoplasmic or nuclear receptors that will allow it to act as a transcription factor and ultimately alter gene expression of the cell.

Detailed explanation-4: -Steroid hormones can pass through the plasma membrane by simple diffusion because they are lipid derived hormones, which means that they are capable of passing through every cell of our body. Unlike other types of hormones, steroid hormones do not have to bind to plasma membrane receptors.