PATHOLOGY

Detailed explanation-1: -It is involved in calcium and bone metabolism. T3 and T4 increase the basal metabolic rate. They make all of cells in the body work harder, so the cells need more energy too.

Detailed explanation-2: -Metabolism: thyroid hormone increases the basal metabolic rate. It increases the gene expression of Na+/K+ ATPase in different tissues leading to increased oxygen consumption, respiration rate, and body temperature. Depending on the metabolic status, it can induce lipolysis or lipid synthesis.

Detailed explanation-3: -Local activation of thyroxine (T4), to the active form, triiodothyronine (T3), by 5′-deiodinase type 2 (D2) is a key mechanism of TH regulation of metabolism. D2 is expressed in the hypothalamus, white fat, brown adipose tissue (BAT), and skeletal muscle and is required for adaptive thermogenesis.

Detailed explanation-4: -TSH causes cells within your thyroid to make more T3 and T4 hormone. If there is too much T4 in your bloodstream your pituitary produces less TSH, which causes your thyroid activity to slow. If there is not enough T4 hormone the pituitary increases the amount of TSH to help speed up your metabolism.

Detailed explanation-5: -The thyroid gland secretes two main hormones, thyroxine and triiodothyronine, into the bloodstream. These thyroid hormones stimulate all the cells in the body and control biological processes such as growth, reproduction, development, and metabolism.