PATHOLOGY

Detailed explanation-1: -Insulin and glucagon work in what’s called a negative feedback loop. During this process, one event triggers another, which triggers another, and so on, to keep your blood sugar levels balanced.

Detailed explanation-2: -Thus, insulin and glucagon actions on blood glucose levels mediate two negative feedback loops in which insulin acts as a repressor, while glucagon as activator (Fig. 1b). Failure of beta cells to secrete insulin in diabetic patients results in uncontrolled fluctuations in blood glucose levels.

Detailed explanation-3: -As blood sugar levels rise, the pancreas produces insulin, a hormone that prompts cells to absorb blood sugar for energy or storage.