PATHOLOGY

Detailed explanation-1: -Instead, a non-steroid hormone binds to a receptor on the cell membrane (see Figure below). The binding of the hormone triggers an enzyme inside the cell membrane. The enzyme activates another molecule, called the second messenger, which influences processes inside the cell.

Detailed explanation-2: -ACTH works on G protein-coupled receptors on extracellular membranes on zona fasciculata and zona reticularis of the adrenal cortex. cAMP is the secondary messenger system. Activation of the g-couple receptor activates adenylyl cyclase, thus increase cAMP production.