PATHOLOGY MCQ
GENETICS AND DISEASE
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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(3.3) Scientists studying human diseases often use animal models. For example, fruit flies have been used to study Alzheimer’s disease. Scientists insert certain human genes found in patients with Alzheimer’s disease into fruit flies and observe how these genes affect the fruit flies. Where must the human gene be inserted for a fruit fly to produce offspring with this gene?
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in the sex cells of the fly
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on several proteins in a fly cell
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in the nervous system of the fly
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on several chromosomes in a fly cell
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Explanation:
Detailed explanation-1: -The animal model is a key tool in quantitative genetics and has been used extensively to estimate fundamental parameters, such as additive genetic variance or heritability. An implicit assumption of animal models is that all founder individuals derive from a single population.
Detailed explanation-2: -Transgenic animals have been used to study aspects of tumor development, immune regulation, cardiovascular development and atherosclerosis. These studies have provided new insights into the genetic origin of certain diseases and have improved our understanding of pathological processes on the cellular level.
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