PATHOLOGY MCQ
GENETICS AND DISEASE
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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pass the carrier state to his male children.
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pass the carrier state to all of his children.
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pass the carrier state to his female children.
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not pass on the genetic mutation to any of his children.
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Detailed explanation-1: -If only the father or the mother has the mutated X-linked gene, the daughters are usually not affected and are called carriers because one of their X chromosomes has the mutation but the other one is normal. Sons will be affected if they inherit the mutated X-linked gene from their mother.
Detailed explanation-2: -Females may get the defective gene either from her mother’s defective X, or, if her father has the disorder, from her father. In either case, the girl will be a carrier and will probably pass the defect to her offspring.
Detailed explanation-3: -One of the ways a genetic trait or condition caused by a mutated (changed) gene on the X chromosome can be passed down (inherited) from parent to child. In X-linked recessive inheritance, a daughter inherits a single mutated gene on the X chromosome from one of her parents.
Detailed explanation-4: -X linked Recessive Inheritance A male with an affected allele on his single X chromosome is hemizygous and can not transmit the disorder to their male offsprings, but all his daughters would be obligate carriers. Healthy heterozygous carrier females pass the disorder to affected sons.