PATHOLOGY

Detailed explanation-1: -If both parents are affected, all children will be affected. If both parents are unaffected heterozygotes, each child has a 25% chance of being affected and a 50% chance of being an unaffected heterozygous carrier of the disorder.

Detailed explanation-2: -If only one parent carries a mutation, there is: A 50% chance in each pregnancy that their child will receive the mutation and be a carrier. A 50% chance in each pregnancy that their child will not receive the mutation and will not be a carrier or have the condition.

Detailed explanation-3: -If you are born to parents who both carry the same autosomal recessive gene, you have a 25% (1 in 4) chance of inheriting the abnormal gene from both parents and developing the disease. You have a 50% (1 in 2) chance of inheriting one abnormal gene. This would make you a carrier.

Detailed explanation-4: -Autosomal recessive inheritance: Two unaffected people who each carry one copy of the altered gene for an autosomal recessive disorder (carriers) have a 25 percent chance with each pregnancy of having a child affected by the disorder.