PATHOLOGY

Detailed explanation-1: -Having sickle cell trait provides malarial protection, but having sickle cell anemia (HbSS) does not. A study of children in Kenya between 16 months and 2 years old showed that those with HbSS had the lowest chance of surviving malaria. However, kids with SCT had the highest chance of survival.

Detailed explanation-2: -The sickle cells have membranes, stretched by their unusual shape, that become porous and leak nutrients that the parasites need to survive and the faulty cells eventually get eliminated quite fast by the organisms, destroying the parasite along the way.

Detailed explanation-3: -Carriers of the sickle cell trait are particularly resistant to severe malarial episodes; they are less resistant to mild cases. The mechanism by which carriers are protected from malaria is different than the acquired immunity that both AA and AS individuals achieve following repeated exposure to the disease.

Detailed explanation-4: -Having one copy of the sickle cell gene may help protect you from a malaria infection. But two copies of the gene may increase your risk of death from malaria. Malaria is a potentially life threatening condition. Mosquitoes infected with a parasite called Plasmodium transmit malaria through their bites.