PATHOLOGY

Detailed explanation-1: -Silent mutations are base substitutions that result in no change of the amino acid or amino acid functionality when the altered messenger RNA (mRNA) is translated.

Detailed explanation-2: -A nucleotide substitution that changes the corresponding amino acid in the protein is called a nonsynonymous substitution (denoted as KA), whereas a nucleotide substitution that does not change the amino acid in the protein is called a synonymous substitution (denoted as KS).

Detailed explanation-3: -A silent substitution is a point mutation that changes one DNA nucleobase to another but does not change the amino acid for which the mutated nucleobase codes.

Detailed explanation-4: -A silent mutation (quiet mutation) is a form of mutation that does not cause a major change in the amino acid. As a result, the protein remains active and functional. Because of this, the changes are viewed as though they are neutral in terms of evolution.

Detailed explanation-5: -The resulting RNA sequence is then translated via the genetic code. The genetic code (shown below) is the “rules” governing the translation of specific RNA trinucleotide codons into the appropriate amino acids. The Genetic Code. Silent mutations are a type of point mutation, also called substitution mutations.