PATHOLOGY

Detailed explanation-1: -Definition. A pedigree, as related to genetics, is a chart that diagrams the inheritance of a trait or health condition through generations of a family.

Detailed explanation-2: -You may not always be able to determine the genotype of an individual based on a pedigree. Sometimes an individual can either be homozygous dominant or heterozygous for a trait. Often, we can use the relationships between an individual and their parents, siblings, and offspring to determine genotypes.

Detailed explanation-3: -A diagram of family history that uses standardized symbols. A pedigree shows relationships between family members and indicates which individuals have certain genetic pathogenic variants, traits, and diseases within a family as well as vital status.

Detailed explanation-4: -If both parents are affected and an offspring is unaffected, the trait must be dominant (parents are both heterozygous) All affected individuals must have at least one affected parent. If both parents are unaffected, all offspring must be unaffected (homozygous recessive)