PATHOLOGY

Detailed explanation-1: -Sickle cell disease (SCD) is a genetic disorder caused by a mutation in both copies of a person’s HBB gene. This gene encodes a component of hemoglobin, the oxygen-carrying protein in red blood cells. The mutation causes hemoglobin molecules to stick together, creating sickle-shaped red blood cells.

Detailed explanation-2: -Sickle Cell Anemia: occurs when an abnormal hemoglobin S gene is inherited from both parents. The red blood cells are normally shaped like a disc but the distorted red blood cells of sickle cell anemia are shaped like crescents.

Detailed explanation-3: -Sickle cell disease is a hereditary disease seen most often among people of African ancestry. Caused by mutations in one of the genes that encode the hemoglobin protein, the disease is inherited as an autosomal recessive trait. The mutation causes the red blood cells to take on an unusual sickle shape.

Detailed explanation-4: -Thalassemia is an inherited (i.e., passed from parents to children through genes) blood disorder caused when the body doesn’t make enough of a protein called hemoglobin, an important part of red blood cells.

Detailed explanation-5: -Sickle cell disease is an inherited blood disorder marked by defective hemoglobin. It inhibits the ability of hemoglobin in red blood cells to carry oxygen. Sickle cells tend to stick together, blocking small blood vessels causing painful and damaging complications.